Neurogenetics II: complex disorders
Identifieur interne : 000367 ( Main/Exploration ); précédent : 000366; suivant : 000368Neurogenetics II: complex disorders
Auteurs : A. WrightSource :
- Journal of Neurology, Neurosurgery, and Psychiatry [ 0022-3050 ] ; 2005.
Abstract
The genetic analysis of common neurological disorders will be a difficult and protracted endeavour. Genetics is only one of many disciplines that will be required but it has already thrown considerable light on the aetiology of several major neurological disorders through the analysis of rare inherited subgroups. The identification of individual susceptibility genes with variants of smaller effect will be more difficult but there is no sharp demarcation between large and small genetic effects, so that many new and important insights will emerge using existing and new technologies. The availability of improved neuroimaging, better animal models of disease and new genetic tools, such as high-throughput gene chips, expression microarrays and proteomics, are extending the range of traditional genetic mapping tools. Finally, an understanding of the genetic and epigenetic mechanisms that restrain the differentiation and integration of human neural stem cells into mature neuronal networks could have a major impact on clinical practice. These approaches will be illustrated in the context of Alzheimer disease, Parkinson disease and synucleinopathies, tauopathies, amyotrophic lateral sclerosis and stroke.
Url:
DOI: 10.1136/jnnp.2004.047704
PubMed: 15834017
PubMed Central: 1739632
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000320
- to stream Pmc, to step Curation: 000208
- to stream Pmc, to step Checkpoint: 000182
- to stream Ncbi, to step Merge: 000014
- to stream Ncbi, to step Curation: 000014
- to stream Ncbi, to step Checkpoint: 000014
- to stream Main, to step Merge: 000368
- to stream Main, to step Curation: 000367
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neurogenetics II: complex disorders</title><author><name sortKey="Wright, A" sort="Wright, A" uniqKey="Wright A" first="A" last="Wright">A. Wright</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15834017</idno><idno type="pmc">1739632</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1739632</idno><idno type="RBID">PMC:1739632</idno><idno type="doi">10.1136/jnnp.2004.047704</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">000320</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000320</idno><idno type="wicri:Area/Pmc/Curation">000208</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000208</idno><idno type="wicri:Area/Pmc/Checkpoint">000182</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000182</idno><idno type="wicri:Area/Ncbi/Merge">000014</idno><idno type="wicri:Area/Ncbi/Curation">000014</idno><idno type="wicri:Area/Ncbi/Checkpoint">000014</idno><idno type="wicri:doubleKey">0022-3050:2005:Wright A:neurogenetics:ii:complex</idno><idno type="wicri:Area/Main/Merge">000368</idno><idno type="wicri:Area/Main/Curation">000367</idno><idno type="wicri:Area/Main/Exploration">000367</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Neurogenetics II: complex disorders</title><author><name sortKey="Wright, A" sort="Wright, A" uniqKey="Wright A" first="A" last="Wright">A. Wright</name></author></analytic><series><title level="j">Journal of Neurology, Neurosurgery, and Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p> The genetic analysis of common neurological disorders will be a difficult and protracted endeavour. Genetics is only one of many disciplines that will be required but it has already thrown considerable light on the aetiology of several major neurological disorders through the analysis of rare inherited subgroups. The identification of individual susceptibility genes with variants of smaller effect will be more difficult but there is no sharp demarcation between large and small genetic effects, so that many new and important insights will emerge using existing and new technologies. The availability of improved neuroimaging, better animal models of disease and new genetic tools, such as high-throughput gene chips, expression microarrays and proteomics, are extending the range of traditional genetic mapping tools. Finally, an understanding of the genetic and epigenetic mechanisms that restrain the differentiation and integration of human neural stem cells into mature neuronal networks could have a major impact on clinical practice. These approaches will be illustrated in the context of Alzheimer disease, Parkinson disease and synucleinopathies, tauopathies, amyotrophic lateral sclerosis and stroke. </p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Wright, A" sort="Wright, A" uniqKey="Wright A" first="A" last="Wright">A. Wright</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Psychologie/explor/DanceTherParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000367 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000367 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Psychologie
|area= DanceTherParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:1739632
|texte= Neurogenetics II: complex disorders
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:15834017" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a DanceTherParkinsonV1
| This area was generated with Dilib version V0.6.35. |  |